EMBRYO BIOPSY – PREIMPLANTATION GENETIC TESTING PGT
Research has shown that genetic errors in embryos are a major cause of failed pregnancy and miscarriage. Embryos with the incorrect number of chromosomes (also called aneuploid embryos) typically result in a miscarriage or birth of a child with a genetic condition. Embryos with the correct number of chromosomes (also called euploid embryos) have a better chance of leading to a successful pregnancy.
Preimplantation genetic testing PGT (formerly known as preimplantation genetic screening PGS) of embryos identifies embryos with the correct number of chromosomes. After PGT, embryos found to have flaws are discarded and only healthy embryos are transferred into the mother’s womb for a pregnancy. Hence, there is increased chance of successful pregnancy.
As a woman ages, the potential for chromosomally abnormal embryos significantly increases, regardless of the number of embryos produced. PGT-A can help women of all ages increase their chances of a successful pregnancy.
At Genesis, couples interested in PGT testing can consult with the fertility specialist to discuss available procedures. PGT comprises a group of genetic assays used to evaluate embryos before transfer into the uterus.
1. PGT-A – Preimplantation genetic testing-aneuploidy is a broader test that screens for aneuploidy in all chromosomes, including the 22 pairs of autosomes and the sex chromosomes, X and Y
2. PGT-M – Preimplantation genetic testing-monogenic is targeted to single gene disorders
3. PGT-SR – To detect structural chromosomal abnormalities such as translocations, preimplantation genetic testing-structural rearrangements PGT-SR is used.
When is PGT-A Recommended?
- Couple whose multiple IVF cycles have been unsuccessful
- Advanced maternal age, more than 35-year-old
- Women having recurrent pregnancy loss
When is PGT-M Recommended?
- Couples who have a previous pregnancy or a child with a genetic condition
- Couple or family have history of genetic condition – Example, cystic fibrosis, sickle cell anaemia, Tay Sachs disease, Fragile X syndrome, Duchenne muscular dystrophy
Some of the benefits of having PGT at Genesis are:
- Higher chance of successful pregnancy
- Reduced risk of miscarriage
- More confidence in transferring a single embryo, avoiding health risks associated with twin or triplet pregnancies
- Reduced number of IVF cycles needed to achieve pregnancy
- Reducing the time to pregnancy and the costs of extra cycles
PGT-A can easily be added to your IVF treatment plan. Here’s how it works
- Initial process is same as ICSI (Test tube baby), begin with the ovarian stimulation, egg retrieval and fertilisation in the laboratory.
- Embryo grows into blastocyst in 5 days.
- Embryo biopsy is performed and few cells from the outer layer of the embryo are sent for biopsy.
- Embryos are frozen.
- Results may take a up to two weeks.
- Once results are obtained, the best of all the healthy embryos that are free from any chromosomal disorder and genetic conditions are identified. These embryos are placed in the uterus of the female partner.
- Any additional embryos that are free of all medical issues are continued to be frozen for future cycles.
- Abnormal embryos are discarded with couples’ consent
- Pregnancy occurs when the embryo successfully implants into the lining of the wom
Apart from the above mentioned, you would have several more questions in mind. You can get the perfect answer to those questions at Genesis, leading fertility and laparoscopic Centre in Hyderabad. Dr. Narmada Katakam established this fertility centre in 2017 after pursuing her career in the UK for over 13 years. Upon reaching her, you will surely get all the questions answered and the child gift because she believes that life begins here.